The MRI-1 Ventilator is a small animal ventilator designed for use in MRI and other high magnetic field environments. The system comprises a microprocessor-based control unit and a set of remote, pneumatically operated, nonmetallic valves. The MRI-1 can operate by itself or can be controlled and/or monitored by a computer. The MRI-1 operates on the flow-time principle: an inspiratory airflow is established and gated into the animal for a

known time, thus producing a known volume. This approach provides extraordinary flexibility — a wide range of volumes, breaths-per-minute, and I/E ratios are possible with no hardware

changes, and using just three front-panel controls. Respiratory airflow is provided by an internal airpump. Alternatively, an external pressurized gas source can be

attached (oxygen or anesthetic gasses). The remote high-speed, miniature pneumatic valves do the actual airflow switching. By locating these valves close to the animal (including inside the magnet bore if necessary), dead-space and tubing compliance are minimized.

Operation

Setting up and operating the MRI-1 is easy. Two lengths of flexible tubing connect the control unit and the valves; one supplies the inspiratory airflow and the other is the pressure

source for operating the valves. Only three controls are required: RESPIRATORY RATE is set in breaths/minute; the FLOW RATE is set using the front-panel flowmeter (and measured

internally by a mass flowmeter); and the PERCENT INSPIRATION is set to establish the ratio of inspiration to expiration time (I/E ratio). All respiratory parameters are shown on the front-panel

LCD display. The tidal volume and minute ventilation reflecting the current settings is also continuously displayed, and can easily be changed by adjusting the FLOW RATE.

Expandable

Of course, the MRI-1 can also be used in other than magnetic environments. Because of the non-electrical nature of the ventilation valves, this unit is particularly well suited to sensitive electrophysiology recording situations. Besides the standard miniature pneumatic valves, the MRI-1 accepts any of the valve assemblies available for the popular SAR-830 series ventilators. Using the MVA-4 multi-valve expander, it is also possible to ventilate several rodent-sized animals simultaneously using just one MRI-1 as the control unit. The external

valves operate synchronously, but tidal volumes are independently set by varying the flow rate to each valve assembly. A source of compressed air or helium is required for operating the pneumatic valves. This is attached to the rear panel of the unit, and the pressure is internally switched on or off as required for remote valve operation. Helium is often used as the actuating gas because its lower density and viscosity permits somewhat faster valve switching. All models feature switchable 120/240VAC operation.

S P E C I F I C A T I O N S

Respiratory rate range . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  . . . . . . . . . . . 5 - 150 breaths/min

Inspiratory flow range . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . .50 - 1000ml/min

Inspiration/Expiration (I/E ratio) range . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 - 80%

Tidal volume range . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.1 - 30ml

Manual control functions . . . . .  . . . . . . .HOLD (suspends inspiration), MAN (manual inflation)

LCD panel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4 lines x 20 chars, backlit

Indicator lights . . . . . . . . . . . . . . . . . . . . . . . . .INSPIRATION, LOW PRES WARNING, ERROR

Internal airpump capacity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 lpm

Pneumatic valve switching speed (air actuation) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .< 75mS

Pneumatic valve switching speed (Helium actuation) . . . . . . . . . . . . . . . . . . . . . . . . . . .. .< 55mS

Pneumatic valve actuation pressure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 - 5 bar

Pneumatic valve flow orifices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.080 in. (2.0mm)

Pneumatic valve materials . . . .PTFE body, non-metallic fasteners, one non-ferrous coil spring

Dimensions, main unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9W x 5.5H x 9D in. (23 x 14 x 23cm)

Dimensions, pneumatic valve (each, of two) . . . . . . . . . . . . . 1.0 dia x 1.8 long, in. (47 x 25mm)

Port connections, respiratory and pressure functions . . . . . . . . . .0.125" (3mm) ID Tygon tubing

SYNC OUT connector . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .BNC

Data Port connector . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .DB-25S

Power requirements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .120/240V (switchable), 100VA